Endocannabinoid System Explained

by , in CBD (Cannabidiol)


Notice: Undefined variable: hashy in /home/d3xe3dkepf67/public_html/wp-content/themes/cbd/content.php on line 65

Notice: Undefined variable: hashy in /home/d3xe3dkepf67/public_html/wp-content/themes/cbd/content.php on line 65

Share: Tweet Pin Share

People ask us all the time, what is the endocannabinoid system? The endogenous cannabinoid system, named after the plant (cannabis sativa) that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment.

Cannabinoids promote homeostasis (balance-harmony) at every level of biological life, from the sub-cellular, to the organism, and perhaps to the community and beyond. Here’s one example: autophagy, a process in which a cell sequesters part of its contents to be self-digested and recycled, is mediated by the cannabinoid system. While this process keeps normal cells alive, allowing them to maintain a balance between the synthesis, degradation, and subsequent recycling of cellular products, it has a deadly effect on malignant tumor cells, causing them to consume themselves in a programmed cellular suicide. The death of cancer cells, of course, promotes homeostasis and survival at the level of the entire organism.

Endocannabinoids and cannabinoids are also found at the intersection of the body’s various systems, allowing communication and coordination between different cell types. At the site of an injury, for example, cannabinoids can be found decreasing the release of activators and sensitizers from the injured tissue, stabilizing the nerve cell to prevent excessive firing, and calming nearby immune cells to prevent release of pro-inflammatory substances. Three different mechanisms of action on three different cell types for a single purpose: minimize the pain and damage caused by the injury.

The endocannabinoid system, with its complex actions in our immune system, nervous system, and all of the body’s organs, is literally a bridge between body and mind. By understanding this system we begin to see a mechanism that explains how states of consciousness can promote health or disease.

In addition to regulating our internal and cellular homeostasis, cannabinoids influence a person’s relationship with the external environment. Socially, the administration of cannabinoids clearly alters human behavior, often promoting sharing, humor, and creativity. By mediating neurogenesis, neuronal plasticity, and learning, cannabinoids may directly influence a person’s open-mindedness and ability to move beyond limiting patterns of thought and behavior from past situations. Reformatting these old patterns is an essential part of health in our quickly changing environment.

Endocannabinoid System & Cannabinoid Receptors

Sea squirts, tiny nematodes, and all vertebrate species share the endocannabinoid system as an essential part of life and adaptation to environmental changes. By comparing the genetics of cannabinoid receptors in different species, scientists estimate that the endocannabinoid system evolved in primitive animals over 600 million years ago.

While it may seem we know a lot about cannabinoids, the estimated twenty thousand scientific articles have just begun to shed light on the subject. Large gaps likely exist in our current understanding, and the complexity of interactions between various cannabinoids, cell types, systems and individual organisms challenges scientists to think about physiology and health in new ways. The following brief overview summarizes what we do know.

Cannabinoid receptors are present throughout the body, embedded in cell membranes, and are believed to be more numerous than any other receptor system. When cannabinoid receptors are stimulated, a variety of physiologic processes ensue. Researchers have identified two cannabinoid receptors: CB1, predominantly present in the nervous system, connective tissues, gonads, glands, and organs; and CB2, predominantly found in the immune system and its associated structures. Many tissues contain both CB1 and CB2 receptors, each linked to a different action. Researchers speculate there may be a third cannabinoid receptor waiting to be discovered.

Endocannabinoids are the substances our bodies naturally make to stimulate these receptors. The two most well understood of these molecules are called anandamide and 2-arachidonoylglycerol (2-AG). They are synthesized on-demand from cell membrane arachidonic acid derivatives, have a local effect and short half-life before being degraded by the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Phytocannabinoids are plant substances that, because of their similar molecular shape to endocannabinoids, are able to stimulate endocannabinoid receptors both directly and indirectly. There are currently 111 known cannabinoids found in the cannabis sativa plant. THC, the psychoactive cannabinod, and CBD the non psychoactive cannabinoid, have a wide range of health applications, (see conditions) and are by far the most prevalent cannabinoids contained in the cannabis sativa plant.

Here at IwantmyCBD.org, we are dedicated to ensuring your right to obtain CBD legally. We are working hard to make sure CBD rich hemp oil remains a dietary supplement. To see what we are up to, sign up for the I want my CBD Newsletter. If you feel that CBD is right for you and want to join the fight to protect your access to CBD, you can help by liking us on Facebook, or following us on Twitter or Pinterest. Join us in spreading the word on CBD and let’s keep the momentum going!

I want my CBD: Top Reviewed CBD Products 2019

Cannabitol Full-Spectrum Hemp Oil 500 OilCannabitol Full-Spectrum Hemp Oil 500 Oil

ECS5™ Cannabitol Full Spectrum Hemp CBD Oil 500MG

HempLand USA

$59

100/100 

  • Price:$59.95 
  • Total CBD:602mg
  • Servings/Size:30/1ml
  • CBD Per Dose:20.1mg

Product Review Buy

Cannabitol 750 Full-Spectrum Hemp Oil 25mg Soft Gels PillCannabitol 750 Full-Spectrum Hemp Oil 25mg Soft Gels Pill

Cannabitol 750 THC Free CBD Hemp Oil Soft Gels

HempLand USA

$99

99/100 

  • Price:$99.00 
  • Total CBD:772mg
  • Servings/Size:30/1ml
  • CBD Per Dose:25.7mg

Product Review Buy

CBDistillery Full Spectrum CBD Oil Tincture 500MG

CBDistillery

$72

85/100 

  • Price:$72.95 
  • Total CBD:510mg
  • Servings/Size:30/1ml
  • CBD Per Dose:17.0mg

Product Review Buy

Charlotte's Web Original Formula Hemp Extract

Charlotte's Web

$149

82/100 

  • Price:$149.95 
  • Total CBD:2003mg
  • Servings/Size:30/1ml
  • CBD Per Dose:66.8mg

Product Review Buy

Article Resources

Share: Tweet Pin Share

Tags: Cannabidiol, CBD, Endocannabinoid System, Hemp, Marijuana

Next Article:

Back To: Home, Blog, CBD Product Reviews

Follow IwantmyCBD on:

IwantmyCBD Newsletter Sign Up

Download the I Want My CBD Book Absolutely Free!

In 2014 when I wrote the little book entitled I Want My CBD I had no idea how popular it would instantly become. The book almost single handedly brought about the current demand for all things CBD. Some readers individually ordered hundreds of copies to give to their family and friends. Churches ordered thousands of copies to pass out during services. Besides the general public, veteran groups, nurses, doctors, healers of every stripe wanted copies of I Want My CBD. Download your Free copy now and share it with a friend.

DownloadCBD Newsletter

Best CBD Products 2021

Cannabitol Full-Spectrum Hemp Oil 500 OilCannabitol Full-Spectrum Hemp Oil 500 Oil

Cannabitol® ECS5™ Enhanced—Full Spectrum—Hemp CBD Oil—5000mg

HempLand USA

$59

100/100 

  • Price:$59.95 
  • Total CBD:5231mg
  • Servings/Size:60/1ml
  • CBD Per Dose:87.2mg

Product Review Buy

Cannabitol Full-Spectrum Hemp Oil 500 OilCannabitol Full-Spectrum Hemp Oil 500 Oil

Cannabitol®—Full Spectrum—Hemp CBD Oil—5000mg

HempLand USA

$59

100/100 

  • Price:$59.95 
  • Total CBD:5168mg
  • Servings/Size:60/1ml
  • CBD Per Dose:86.1mg

Product Review Buy

Cannabitol Full-Spectrum Hemp Oil 500 OilCannabitol Full-Spectrum Hemp Oil 500 Oil

Cannabitol®—THC FREE—Hemp CBD Oil—5000mg

HempLand USA

$59

100/100 

  • Price:$59.95 
  • Total CBD:5211mg
  • Servings/Size:60/1ml
  • CBD Per Dose:86.9mg

Product Review Buy