Non-Psychoactive CBD Oil – No High Cannabinoids

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The 7 Most Helpful Cannabinoids That Won’t Get You High

The cannabis plant, called Cannabis Sativa, is an amazing herb that produces over 421 chemical compounds.

Of the 421, about 80 have been found to be terpeno-phenol compounds which have not been detected in any other plant. These 80 compounds that occur naturally in the cannabis plant are cannabinoids that have collectively been given the named phytocannabinoids.

One major cannabinoid is the psychoactive ∆9-THC, delta-9-tetrahydrocannabinol (THC). Unfortunately, even though THC has proven to be useful in treating a variety of ailments, many patients simply don’t want to get “high”.

Yet even if they can tolerate the high, generally people are unable to tolerate high doses of THC and therefore miss out on some of its benefits. In other words, THC’s psychotropic effects have greatly limited its clinical use.

Fortunately, some cannabinoids are non-psychoactive. In fact, the cannabis plant contains many cannabinoids with weak or no psychoactivity at all, and therapeutically, might be more promising than THC.

Cannabidiol or CBD is the major phytocannabinoid that fits into this category. Not only has CBD been used successfully to treat a range of health problems, it doesn’t activate the cannabinoid receptors like THC which likely explains its lack of psychotropic activity.

Likewise, ∆9-THCV, Delta-9-tetrahydrocannabivarin; CBG, cannabigerol; CBC, cannabichromene; CBDA, cannabidiolic acid; ∆9-THCA, Delta-9- tetrahydrocannabinolic acid; and CBDV, cannabidivarin, are phytocannabinoids that also lack psychoactive activity but are also proving to be very useful in treating a variety of conditions.

In this article, we explore the potential therapeutic applications for 7 of the most helpful cannabinoids that won’t get you high. And first, we’ll start with CBD.

  1. Cannabidiol or CBD

    Over the last few decades, research into CBD has uncovered a growing list of useful health benefits for users. Instead of activating CB1 and CB2 cannabinoid receptors like THC, CBD works as a “multi-target” drug by interacting with other non-endocannabinoid signaling systems.

    Here are some of the important pharmacological actions of CBD:

    • Anxiolytic – activation of 5-HT1A receptors to inhibit anxiety
    • Antipsychotic – activation of transient receptor potential vanilloid type 1 (TRPV1) to help manage psychosis
    • Antiepileptic – decreases Ca2+ to help with epilepsy
    • Neuroprotective – decreases Ca2+, decreases ROS (reactive oxygen species) to help with brain function
    • Vasorelaxant – activation of PPARy helps reduce tension in blood vessel walls
    • Antispasmodic – Antagonist of CB1/CB2 agonists to relieve spasms of involuntary muscles
    • Anti-ischemic – activation of 5-HT1A to help improve blood flow to the heart.
    • Antiproliferative and Anticancer – increase Ca2+, increase ROS, activate CB2, decrease DNA-binding protein inhibitor (ID-1) for preventing or retarding the spread of cells into surrounding tissues.
    • Antiemetic – shown effectiveness against vomiting and nausea
    • Antibacterial – helps against bacteria infections
    • Antidiabetic – helps lower glucose levels of blood
    • Antipsoriatic – inhibit keratinocyte proliferation to help counter psoriasis
    • Intestinal Anti-prokinetic – CB1 antagonist, down-regulation of the endocannabinoid-degrading enzyme FAAH in the inflamed gut
    • Analgesic – activation of (TRPV1) to help relieve pain
    • Bone stimulant – helps promote bone growth
    • Anti-inflammatory – decreases TNF-a release, decreases Adenosine uptake to reduce inflammation
    • Immunosuppresive – decreases T-cells to help suppress the immune response of an individual
  2. ∆9-THCV, Delta-9-tetrahydrocannabivarin

    THCV is a novel CB1 antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity as an appetite suppressant.

    • Antiepileptic – increases gamma-Aminobutyric acid (GABA), antagonizes CB1, THCV increases central inhibitory neurotransmission with a therapeutic potential in epilepsy
    • Bone stimulant – As a CB2 partial agonist, D9-THCV stimulates mesenchymal stem cells (MSCs) via CB2 receptors and can be linked to bone stimulation, bone growth, and fracture healing.
    • Anorectic – As a CB1 antagonist, decreases food intake through CB1 antagonism. D9-THCV attenuates D9-THC-induced hypothermia and antinociception in vivo.
  3. CBG, cannabigerol

    Cannabigerol or CBG is another cannabinoid found in cannabis that is non-psychoactive. It is usually found in higher concentrations in hemp.

    CBG has been found to act as a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist. It also binds to the CB2 receptor, but whether it acts as an agonist or antagonist at this site is not fully understood.

    CBG has been shown to relieve intraocular pressure in the eye, which may be of benefit in the treatment of glaucoma. It has been shown to improve a model of inflammatory bowel disease induced experimentally in mice. CBG can also inhibit the uptake of GABA in the brain, which can decrease anxiety and muscle tension.

    • Antiproliferative – for preventing or retarding the spread of cells into surrounding tissues
    • Antibacterial – helps against bacteria infections
    • Bone stimulant – helps promote bone growth, formation, and fracture healing.
  4. CBC, cannabichromene

    The non-psychoactive phytocannabinoid, Cannabichromene or CBC, is the second most abundant cannabinoid found in the cannabis plant. CBC is known to interact with many receptors in the brain. It is widely known that the cannabinoids interact with the CB1 and CB2 receptors, but they also interact with others. Researchers have found CBC to have pharmacological relevance as an:

    • Anti-inflammatory – modulated by the administration of THC and is independent of the CB2 receptor. This suggests an interplay of the two molecules
    • Analgesic – TRPA1 agonist to help relieve pain
    • Bone stimulant – helps promote bone formation and fracture healing.
    • Antimicrobial and antifungal – exhibits “strong” antibacterial effects on a variety of gram-positive, gram-negative and acid-fast bacteria – including E. coli and staph. Also shows “mild to moderate” activity against different types of fungi
    • Antiproliferative – for preventing or retarding the spread of cells into surrounding tissues
  5. CBDA, cannabidiolic acid

    CBDA was the first cannabinoid acid to be discovered. The acid was isolated by Krejci and Santavy in 1955.

    CBDA is the main component of glandular hairs (up to 15%) along with CBD. In fresh plant material, 95% of CBD exists as its acid. It is a selective COX-2 inhibitor, which could have a potential role in inflammation. It is a partial TRPA1 and TRPV1 agonist, which could play a role in analgesia. CBDA is also a TRPM8 antagonist, which is linked to analgesia and could help in the treatment of prostate carcinoma.

  6. ∆9-THCA, Delta-9- tetrahydrocannabinolic acid

    THCA is found in fresh and undried cannabis and is actually a precursor to THC, meaning once THCA is dried (especially under intense heat), it becomes THC. It was first extracted by Korte and coworkers in 1965 and was later isolated as a pure compound in 1967 by Nishioka’s group.

    THCA is a potent TRPA1 agonist and TRPM8 antagonist and has been shown to exert anti-proliferative actions for treatment in prostate cancer and anti-spasmodic actions. It is also known to have anti-inflammatory, neuroprotective, and antiemetic (anti-vomiting) effects.

  7. CBDV, cannabidivarin

    Cannabidivarin (CBDV) is another non-psychoactive cannabinoid found in Cannabis.

    Although not much research has focused on CBDV, it is being actively developed because of a demonstrated neurochemical pathway for previously-observed anti-epileptic and anti-convulsive action.

    Mesenchymal stem cells (MSCs) play a central role in bone formation and fracture healing and CBDV has been shown to be a very effective stimulant (100%) for the recruitment of quiescent MSCs present in bone marrow. Along with THCV, and CBD, CBDV, may exert beneficial effects on bone formation and fracture healing.

There you have it. Those are the 7 most helpful cannabinoids that won’t get you high. Clearly, this is an area that remains relatively unexplored and will continue to evolve as more pharmacological effects and potential therapies are discovered. With a ton of new research already underway to study non-psychoactive phytocannabinoids, we’re almost guaranteed that this list will change in the near future.

This is a very exciting time in modern medicine.

Let’s throw our support behind cannabis and help to keep the momentum going.

Here at, we are dedicated to ensuring your right to obtain CBD legally. We are working hard to make sure CBD rich hemp oil remains a dietary supplement. To see what we are up to, sign up for the I want my CBD Newsletter. If you feel that CBD is right for you and want to join the fight to protect your access to CBD, you can help by liking us on Facebook, or following us on Twitter or Pinterest. Join us in spreading the word on CBD and let’s keep the momentum going!

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Tags: Anxiety, cannabinoids, CBD, CBD oil, Glaucoma, Inflammation, Nausea, no high, non-psychoactive, non-psychotropic, Obesity, Osteoporosis Bone Health

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