How much CBD should you take?
Finding the correct CBD dosage
Cannabidiol, or CBD, is the non-psychoactive ingredient in the cannabis sativa plant that has shown immense promise in the treatment of a variety of conditions. It also has no negative side effects, does not damage the body or mind, is not addictive, and cannot be overdosed on.
But how much CBD should you take?
Finding the right dosage can be a challenge, especially when there are so many factors that can alter its effectiveness. The right regimen for treatment will likely depend on who’s taking the CBD and what type of medical condition is being treated.
That being said, successful studies have been conducted on the effectiveness of CBD for treating a wide range of medical conditions. Although more studies have been conducted on rodents rather than humans, the results are applicable because their genetic, biological and behavior characteristics closely resemble those of humans. As a rough guide, you can follow the dosages used by the researchers to get an idea of how much CBD to use when developing a customized treatment program for yourself.
Please be aware that this is not a substitute for expert advice from trained medical professionals. When in doubt, consult your doctor before you embark on any experimental drug treatment.
Furthermore, you should always err on the side of caution when trying CBD for the first time. That means you should always begin with a lower dosage, take fewer doses instead of one large dose, and use the same dose for several days before making any adjustments higher. You should also be mindful not to overuse the product.
So without further ado, here are some common conditions being treated with CBD today and guides to the dosages that were administered by the researchers in these studies:
In a study published in Epilepsy & Behavior in June 2015, researchers surveyed 117 parents of children with epilepsy including children with infantile spasms (IS) and Lennox–Gastaut syndrome (LGS). Once treated with CBD cannabis preparations, 85% of all parents reported a reduction in seizure frequency, and 14% reported complete seizure freedom. The median duration and the median dosage of CBD exposure were 6.8 months and 4.3 mg/kg/day, respectively.
In a study published in the Journal of Psychopharmacology in September 2010, researchers investigated the effects of CBD on patients with generalized social anxiety disorder (SAD) using functional neuroimaging. They found that that CBD reduced anxiety in SAD which is related to its effects on activity in limbic and paralimbic brain areas. Subjects were given an oral dose of CBD (400 mg) or placebo, in a double-blind procedure.
Chronic neuropathic and inflammatory pain:
In a study published in the European Journal of Pharmacology in February 2007, researchers investigated the therapeutic potential of CBD on neuropathic (sciatic nerve chronic constriction) and inflammatory pain in rats. They concluded that CBD was useful for treating chronic pain. The rats were administered daily oral treatment of CBD in dosages of 2.5–20 mg/kg.
In another study published in the British Journal of Pharmacology in February 2014, researchers studied the effects of CBD on mice with chemotherapy-induced neuropathic pain (CIPN) through the 5-HT(1A) receptors (a subtype of the serotonin receptor). They found CBD to be safe and effective in the prevention or attenuation of CIPN. The mice were administered 2.5 – 10 mg/kg of CBD.
Arthritis and osteoporosis:
In a study published in the Proceedings of the National Academy of Sciences of the United States of America or PNAS, researchers tested the effectiveness of CBD for treating murine collagen-induced arthritis (CIA) in mice and concluded that CBD was a potent anti-arthritic treatment. CBD was equally effective when administered through injection or orally. The dose dependency showed a bell-shaped curve, with an optimal effect at 5 mg/kg per day injected or 25 mg/kg per day orally.
In a Ph.D. Thesis by Dr. Aysha Binty Khalid at the University of Aberdeen, Dr. Khalid studied the regulation of bone by cannabinoid and cannabinoid-like receptors. The results of the study suggest that blocking GPR55 with small molecules such as CBD may be beneficial in bone diseases such as osteoporosis. Unfortunately, the experiments were conducted in vitro (in a culture dish) so the dosage of 1 μm (micrometer) CBD added to osteoblasts cultured from human femoral heads (head of the femur) does not really apply to customized home treatment programs, however the results are encouraging.
In a study published in the FEBS Letters in July 2006, researchers studied the effects of CBD on sleep in rats. The results showed that CBD modulates waking via activation of neurons in the hypothalamus and dorsal raphe nucleus (DRD) and might be of therapeutic value in sleep disorders such as excessive somnolence (a state of strong desire for sleep, or sleeping for unusually long periods). CBD was administered direct to the brain with intracerebroventricular (icv) in a dose of 10 μg (microgram)/5 μl (microliter).
In another study published in the Journal of Clinical Psychopharmacology in June 2004, researchers studied the effects of THC and CBD on nocturnal sleep and early-morning behavior in young adults. They found that 15 mg of CBD appeared to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC.
In a study published in Translational Psychiatry in March 2012, researchers studied the effects of CBD on anandamide signaling and schizophrenia. The results suggested that inhibition of anandamide deactivation may contribute to the antipsychotic effects of CBD which could potentially represent a completely new mechanism in the treatment of schizophrenia. Furthermore, CBD was much more tolerable and safe compared with current medications. Patients received CBD starting with 200 mg per day and increased stepwise by 200 mg per day to a daily dose of 200 mg four times daily (total 800 mg per day) within the first week.
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